Mevalonate: Difference between revisions
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'''Mevalonate''' is a key chemical precursor in the biosynthesis of [[cholesterol]]. The statin drugs used to lower cholesterol are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]]s that work by inhibiting the synthesis of mevalonate from the reduction of [[3-hydroxy-3-methyl-glutaryl CoA]] (HMG-CoA). | '''Mevalonate''' is a key chemical precursor in the biosynthesis of [[cholesterol]]. The statin drugs used to lower cholesterol are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]]s that work by inhibiting the synthesis of mevalonate from the reduction of [[3-hydroxy-3-methyl-glutaryl CoA]] (HMG-CoA). | ||
[[Image:Mevalonate synthesis.jpg|left|thumb|250px|{{#ifexist:Template:Mevalonate synthesis.jpg/credit|{{Mevalonate synthesis.jpg/credit}}<br/>|}}Biosynthesis of mevalonate from HMG CoA.]] | [[Image:Mevalonate synthesis.jpg|left|thumb|250px|{{#ifexist:Template:Mevalonate synthesis.jpg/credit|{{Mevalonate synthesis.jpg/credit}}<br/>|}}Biosynthesis of mevalonate from HMG CoA.]] | ||
Its IUPAC chemical name is (3R)-3,5-dihydroxy-3-methylpentanoic acid and its chemical formula is C<sub>6</sub>H<sub>12</sub>O<small>4</small> in the protonated state. | |||
Revision as of 13:19, 24 January 2008
Mevalonate is a key chemical precursor in the biosynthesis of cholesterol. The statin drugs used to lower cholesterol are HMG-CoA reductase inhibitors that work by inhibiting the synthesis of mevalonate from the reduction of 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA).
Its IUPAC chemical name is (3R)-3,5-dihydroxy-3-methylpentanoic acid and its chemical formula is C6H12O4 in the protonated state.