Potassium in nutrition and human health

To maintain health, the diet of humans must contain potassium, in its ionic form (K⁺), usually as potassium salts of organic acids in food (e.g., potassium citrate). In 2004-2006, the Institute of Medicine of the National Academies of Science and its Food and Nutrition Board recommended that adult humans consume 4700 milligrams (mg) of potassium per day, which, calculated from the atomic mass of potassium (39.1 mg per mmol), amounts to 120 millimoles (mmol) potassium per day: 4700 mg/39.1 mg/mmol =120 mmol. That intake of potassium substantially exceeds estimates from recent surveys of average intakes by the general population. Subsequent sections will discuss potassium intake recommendations for children and special groups.

Introduction

Potassium ranks as the most abundant cation (positive ion) inside animal cells (intracellular), and as such contributes critically in numerous important ways to the optimal functioning of cells and therefore to optimal functioning of the organ systems and individuals they compose. Among other metabolic functions, potassium plays a role in the synthesis of proteins and in the biochemical transformations required for carbohydrate metabolism.

The ratio of the concentrations of potassium in intracellular fluid (ICF) to that in the cells' surrounding extracellular fluid (ECF) has important effects on the rate of transmission of electrical activity (pulses) along nerve fibers and skeletal muscle cells, which, among other things, affects the degree of contraction of the smooth muscles of arteries and arterioles (vascular tone). Inasmuch as extracellular potassium varies in the 3-6 mmol/L range, while intracellular potassium concentrations average about 145 mmol/L, similar small changes in extracellular potassium concentration have a greater effect on the ICF-to-ECF potassium concentration ratio than similar small changes in intracellular potassium concentration. Subsequent sections discuss the implication of changes in the ICF-to-ECF potassium concentration ratio in human physiology.

In healthy persons whose daily consumption of potassium does not vary greatly, the amount of potassium consumed equals the amount excreted, by the kidney and gastrointestinal tract predominantly. Physiologists refer to that equality as zero net external body potassium balance.

Disturbances relating to body potassium deficiency may result from:

• inadequate consumption of potassium-containing foods;
• inappropriately large rates of excretion of potassium in urine;
• inappropriate large excretion rates of potassium in feces.

Disturbances relating to body potassium excess may result from:

• drugs and kidney diseases that impair the kidney’s ability to excrete potassium in urine;
• deficiency of hormones that act to promote kidney and gastrointestinal excretion of potassium.

Subsequent sections will elaborate on the above concepts.

Requirements for potassium consumption by humans

Humans must regularly consume potassium because the body does not store it (as it does fat, say), while the kidney continues to excrete it in the urine even when potassium intake ceases. Potassium-rich foods include leafy green vegetables, vine fruits (e.g., squash, tomatoes, cucumbers, etc.), root vegetables, and tree fruits (see below).

The Institute of Medicine of the National Academies of Science and its Food and Nutrition Board recommend as "Adequate Intake" (AI) of potassium, in mmol/day, as 77 and 97 for children ages 1-3 and 4-8 years, respectively, and as 115 and 120 for children 9-13 and 14-18 years, respectively. For adult men and women, ages 19 to >70 years, they recommend an AI of potassium as 120 mmol/day, and the same amount for pregnant women as young as 14 years, increasing to 130 mmol/day for lactating women.

The Institue of Medicine claims:

"The AIs for potassium are based on a level of dietary intake that should maintain lower blood pressure levels, reduce the adverse effects of sodium chloride intake on blood pressure, reduce the risk of recurrent kidney stones, and possibly decrease bone loss."

The claim reflects concerns about inadequate potassium consumption as contributing to hypertension (abnormally high arterial blood pressure through its effect to promote renal retention of sodium chloride), to mitigating dietary sodium chloride ('salt') intake in contributing to hypertension, and to kidney stone and osteoporosis (soft, fracture-prone bones). This article will address those and other health-related effects of inadequate potassium intake in more detail in later sections.

     Actual consumption of potassium by Americans, 2003-2004

The U.S. Department of Agriculture released in 2007 the results of the National Health and Nutrition Examination Survey (NHANES) data for 2003-2004, giving the average values for the consumption of various nutrients, including potassium. The table below shows a comparison of the average values for potassium consumption by Americans (2003-2004) with the recommended amounts given in the preceding section.

Note that in every age group average consumption of potassium falls well below recommended amounts, with American women consuming half the recommended amount on average, and American men about two-thirds.

Potassium Content of Foods

Understanding the biological effects of dietary potassium ions (cations) requires an associated understanding of the nature of the negatively charged ions (anions) that accompany potassium in foods, balancing potassium’s positive charge, thus maintaining electroneutrality. In natural diets not subjected to commercial processing that includes addition of potassium salts—typically potassium chloride—a variety of organic anions (e.g., citrate, fumarate) accompany the potassium ions in foods, in amounts sufficient to nearly balance the positive charge of the potassium ions (i.e., in near chemical equivalent amounts). Following their absorption by the gastrointestinal tract, the body converts a large fraction of those organic anions to bicarbonate (an acid-neutralizing substance, or base), as an end-product of metabolism. Thus, diets with differing amounts of potassium exert potassium-induced biological effects associated and often interacting with the effects of the differing amounts of acid-neutralizing base, bicarbonate, as generated by the body from the potassium-accompanying organic anions. Physiologists often cannot dissect out the specific effects of the co-ions potassium and bicarbonate, when, for example, a person increases their dietary intake of potassium-rich foods, which typically contain bicarbonate-generating organic anions in abundance (see Table 1 and accompanying text).

Table 1 shows the potassium content of the major food groups, indicating the relation of potassium content to the net acid (or bicarbonate) load supplied to the body by each food group (see comments following table). [NB: Bcause potassium ions have a single charge (univalent), 1 millimole (mmol) of potassium equals 1 milliequivalent (meq) of potassium.]

In Table 1, positive (+) and negative (–) values of net acid load represent acid-producing and bicarbonate-producing equivalents, respectively, in the units specified. Values of net acid load: calculated first for individual food items then averaged per food group, as per compositional values in:. Acid load calculations: as described in: Note that net acid-producing foods tend to have much higher ratios of protein-to-potassium than do net bicarbonate-producing foods (regression of net acid load against Protein/Potassium, r=0.48, p=0.05). Note the relatively low values of protein and potassium in the cereal grain group, of which whole grains comprised six of the seven items in the group.

Table 1 reveals a number of important aspects of food potassium:

• Per unit energy content (kilocalories, abbrev: kcal), non-cereal-grain plant foods provide the most abundant source of potassium.
• The top five plant-food sources of potassium (meq/kcal): root vegetables (celeriac, rutabaga, turnips, carrots, parsnips, sweet potato, potato, yams, onions); vegetable fruit (aka vine fruit) (tomatoes, zucchini, eggplant, cucumbers); leafy greens (spinach, lettuce, kale, chard); stalks (celery, broccoli stalks); mushrooms (not strictly a plant).
• The food sources richest in potassium also supply bicarbonate to the body, as indicated by negative values of "net acid load".
• The potassium content in acid-producing foods (animal-source foods and cereal grains) average about one-fifth that of plant-source foods, which do not contain sufficient quantities of bicarbonate-generating organic anions to neutralize the acid generated from protein and other sustances they contain.
• The ratio of protein-to-potassium in plant-source foods falls short of animal-source foods by a factor of 10.
• Legumes provide moderate amounts of potassium with little or no acid or bicarbonate load.

Table 2 lists selected food sources of potassium, showing amounts of potassium for standard portions, in descending order of amount of potassium per 100 kilocalorie of food source. Raw data for the calculations: taken from

[...in progress...]

Potassium deficiency in type 2 diabetes mellitus and in the metabolic syndrome

Potassium deficiency — or at least suboptimal body content of potassium — may play an important role in causing, sustaining or aggravating type 2 diabetes mellitus and metabolic syndrome. The metabolic syndrome, a serious disturbance of body metabolism and physiology, consists of resistance of certain cell types of the body to the ability of the hormone insulin to promote cellular entry of the energy-rich molecule, glucose, and two or more of the following abnormalities: high blood pressure (or use of drugs to control hypertension); high levels of serum triglycerides; low levels of high-density lipoprotein (HDL) cholesterol; overweight; detectable levels of the protein, albumin, in the urine (microalbuminuria). The abnormalities of triglyceride levels typically associate with other blood fat disturbances (dyslipidemia) that foster atherosclerosis (buildup of plaques in artery walls the predispose to reduced blood flow to vital organs (e.g., the heart) and to formation of blood clots that can break off and plug vital vessels to the brain, causing stroke. The biochemical factors that promote clot formation are also stimulated in the metabolic syndrome, and the syndrome appears to be one of a chronic state of inflammation, the typical body response to tisue injury. An etimated 50 million Americans have the metabolic syndrome.

Studies in humans using a technique called nuclear magnetic resonance spectroscopy found cellular potassium deficiency in patients with type 2 diabetes mellitus and in patients with hypertension. The use of such a state-of-the-art technique enabled discovery of intracellular potassium deficiency not likely expected from routine clinical tests.

In addition, the studies indicated more acidity in the cells of patients with hypertension, especially those also having diabetes.

A longitudinal study of nearly two thousand men and women in Finland (ages 35-64 years) found no evidence of an association of potassium intake (indexed as 24-hour urinary potassium excretion) and the incidence of type 2 diabetes. Higher sodium chloride intakes did predict the incidence of type 2 diabetes among the subjects. Yet, from the study data reported, one cannot tell if the authors performed the same type of data analysis for potassium as they did for sodium, nor did they examine whether the ratio of sodium-to-potassium had a stronger association with diabetes incidence than did sodium alone. If the latter, that might suggest that higher potassium intakes, to lower the sodium-to-potassium ratio, might mitigate or eliminate the association with diabetes incidence. Another studied showed that a dietary pattern emphasizing fruit (a potassium-rich food), and deemphasizing foods not especially rich in potassium, reduced the risk of type 2 diabetes. Studies of close to 500 women (teachers) in Iran showed that increasing intake of fruits and vegetables — potassium-and alkali-rich foods — proportionately decreased the chances of the participants having metabolic syndrome, by 30-35%. The investigators also found that higher fruit and vegetable intakes associated with lower levels of a conventional biomarker of inflammation, a common concomitant of the metabolic syndrome.

     Clinical identification of the metabolic syndrome

• From: Source: National Cholesterol Education Program, Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), National Heart, Lung, and Blood Institute, National Institutes of Health, May 2001, and the Grundy Report in 2004.

RISK FACTOR   DEFINING LEVEL   Abdominal Obesity   Waist Circumference   Men   >102 cm (>40 in)   Women   >88 cm (>35 in)   Triglycerides   >150 mg/dL   HDL Cholesterol      Men   <40 mg/dL   Women   <50 mg/dL   Blood Pressure   =/>130 (systolic) / =/>85 mm (diastolic) Hg   Fasting Blood Glucose   =/>110 mg/dL

Overweight and obesity associate with insulin resistance and the metabolic syndrome. But abdominal obesity correlated more highly with the metabolic risk factors than did an elevated body mass index (BMI). Therefore, NHLBI recommends the simple measure of waist circumference to identify the body weight component of the metabolic syndrome. Some male patients develop multiple metabolic risk factors with waist circumferences only marginally increased, e.g., 94-102 cm (37-39 in). Such patients may have a strong genetic contribution to insulin resistance. They should benefit from changes in life habits, similarly to men with categorical increases in waist circumference.

Potassium Intake, Blood Pressure Regulation, and Risk of Heart Disease and Stroke

Intervention-type research in humans has found that raising potassium intakes reduces blood pressure in the arteries (arterial hypertension). In both the population at large and in people with “high blood pressure” (aka “hypertension”), increasing potassium intake by 30-60 meq/day within the range of low (e.g., 30 meq/day) to high (e.g., 200 meq/day) intakes——either from food or prescribed supplements——tends to lower blood pressure. The degree of blood pressure-lowering depends on a variety of factors, including amount of increase in potassium intake and ancestry.

Because people with higher blood pressures have greater risks of death from heart disease (e.g., heart attacks) and stroke (blockage or leakage of blood vessel in the brain), dietary potassium’s effect in helping keep blood pressures lower in part justified setting the recommended intake of potassium at 120 meq/day---substantially higher than the population average---for American adults by the Institute of Medicine in 2005.

These correspondences in part helped justify the Institute of Medicine’s recommendation to American adults to increase their intake of potassium to 120 meq/day:

• Risk both for heart disease and stroke increases in people with hypertension

• Blood pressures decrease with higher potassium intakes.

• Higher potassium intakes reduce stroke risk independent of blood pressure.

The IOM makes no statement whether 120 meq/day potassium intake ‘’optimizes’’ cardiovascular health, but it sets no upper limit restrictions on potassium intake from food, which could reach 200-300 meq/day. Diets that potassium-rich include diets emphasizing the available abundant variety of potassium-rich vegetables and fruits, and deemphasizing fatty animal-source foods (like fatty hamburger meat) and high-fat-or-high-refined-carbohydrate foods with little-or-no additional nutrient content (like vegetable oil or pancake syrup)—diets considered health-fostering in many ways besides mitigating high blood pressure tissue injury.

Research has not determined optimal potassium intake ranges for maximal protection against heart disease and stroke and other detrimental effects of hypertension.

Dietary Potasium and Risk of Osteoporosis

[...in progress...]

Dietary Potassium and Risk of Kidney Stones

[...in progress...]