BRCA2 gene: Difference between revisions
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imported>Robert Badgett (New page: In physiology, '''BRCA2 gene''' ('''BRCA-2 gene''') is "a tumor suppressor gene located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the for...) |
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In [[physiology]], '''BRCA2 gene''' ('''BRCA-2 gene''') is "a [[tumor suppressor gene]] located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."<ref>{{MeSH}}</ref> | In [[physiology]], '''BRCA2 gene''' ('''BRCA-2 gene''') is "a [[tumor suppressor gene]] located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."<ref>{{MeSH}}</ref> | ||
Women who have [[BRCA1 gene|BRCA1]] or BRCA2 genes, especially if there is a familial history of [[breast cancer]], may be candidates for prophylactic [[mastectomy]]. <ref>{{citation | |||
| journal = J Natl Cancer Inst | |||
| volume=93 | issue = 21 | |||
| pages = 1633-1637 | |||
| author = Hartmann LC ''et al.'' | |||
| title = Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers | |||
| url = http://jnci.oxfordjournals.org/cgi/content/full/93/21/1633}}</ref> | |||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] |
Latest revision as of 12:00, 15 July 2024
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In physiology, BRCA2 gene (BRCA-2 gene) is "a tumor suppressor gene located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."[1]
Women who have BRCA1 or BRCA2 genes, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]
References
- ↑ Anonymous (2024), BRCA2 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637