Aminostatic hypothesis

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In 1956, Mellinkoff proposed the aminostatic hypothesis, stimulated by the observation that when normal individuals ingest protein, appetite diminishes as the serum amino acid concentration rises and vice versa.

Experimental Evidence

-experimental evidence has agreed with the aminostatic hypothesis

-they have found that high protein diets act on satiety and thermogenesis

Use as a method of weight loss

Obesity is everywhere. Around 33% of American adults and 17% of children are obese. In the UK, the statistics are not looking much brighter with 25% of adults and 10% of children showing signs of obesity. It has been proposed in the UK that 60% of men, 50% of women and 25% of children will become obese by 2050 if no preventative measures are taken. This growing prevalence of obesity needs a solution. Many hypotheses regarding different weight loss diets have been proposed. So how can the aminostatic hypothesis be used for treatment? Perhaps a high protein diet is the answer.

• What does the diet consist of? Benefits of high protein diet with supporting evidence (2,3,7,8,10). Animal/veg protein best?

Limitations

-are there any downsides to a high protein diet?

-appetite is a feeling so different participants in experiments may report it differently and so results may not be completely accurate

• Consequent effects on renal function. Usually low carb diet is needed along with HP diet to gain full beneficial effects (subjects more satisfied).