Proton pump inhibitor: Difference between revisions
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In [[medicine]], '''proton pump inhibitors''' ('''PPI''') are [[medication]]s that "inhibit H(+)-K(+)-exchanging atpase. They are used as [[anti-ulcer agent]]s and sometimes in place of [[histamine H2 antagonist]]s for [[gastroesophageal reflux]]."<ref>{{MeSH}}</ref> | In [[medicine]], '''proton pump inhibitors''' ('''PPI''') are [[medication]]s that "inhibit H(+)-K(+)-exchanging atpase. They are used as [[anti-ulcer agent]]s and sometimes in place of [[histamine H2 antagonist]]s for [[gastroesophageal reflux]]."<ref>{{MeSH}}</ref> They are also used as part of curative [therapy for ''[[Helicobacter pylori]]'', in combination with [[antibiotic]]s. | ||
==Adverse effects== | ==Adverse effects== | ||
[[Proton pump inhibitor]]s may be associated with [[spontaneous bacterial peritonitis]].<ref name="pmid19337238">{{cite journal |author=Bajaj JS, Zadvornova Y, Heuman DM, ''et al.'' |title=Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites |journal=Am. J. Gastroenterol. |volume=104 |issue=5 |pages=1130–4 |year=2009 |month=May |pmid=19337238 |doi=10.1038/ajg.2009.80 |url=http://dx.doi.org/10.1038/ajg.2009.80 |issn=}}</ref> These drugs may also be associated with [[pneumonia]], ''[[Clostridium difficile]]'' diarrhea, and [[fracture]]s. | [[Proton pump inhibitor]]s may be associated with [[spontaneous bacterial peritonitis]].<ref name="pmid19337238">{{cite journal |author=Bajaj JS, Zadvornova Y, Heuman DM, ''et al.'' |title=Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites |journal=Am. J. Gastroenterol. |volume=104 |issue=5 |pages=1130–4 |year=2009 |month=May |pmid=19337238 |doi=10.1038/ajg.2009.80 |url=http://dx.doi.org/10.1038/ajg.2009.80 |issn=}}</ref> These drugs may also be associated with [[pneumonia]], ''[[Clostridium difficile]]'' diarrhea, and [[fracture]]s. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 22:32, 31 May 2009
In medicine, proton pump inhibitors (PPI) are medications that "inhibit H(+)-K(+)-exchanging atpase. They are used as anti-ulcer agents and sometimes in place of histamine H2 antagonists for gastroesophageal reflux."[1] They are also used as part of curative [therapy for Helicobacter pylori, in combination with antibiotics.
Adverse effects
Proton pump inhibitors may be associated with spontaneous bacterial peritonitis.[2] These drugs may also be associated with pneumonia, Clostridium difficile diarrhea, and fractures.
References
- ↑ Anonymous (2024), Proton pump inhibitor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Bajaj JS, Zadvornova Y, Heuman DM, et al. (May 2009). "Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites". Am. J. Gastroenterol. 104 (5): 1130–4. DOI:10.1038/ajg.2009.80. PMID 19337238. Research Blogging.