Staphylococcus epidermidis: Difference between revisions
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Most infections caused by ''S. epidermidis'' affect hospital patients because these organisms develop structures called biofilms on the surface of implanted medical devices. These biofilms result from the agglomeration of bacterial cells that are contained in an exopolysaccharide matrix, the slime, to produce a very dense and protected environment from the host defense systems and antibiotics. They not only provide protection from the host but they also result in the damage of surrounding tissues of the host. | Most infections caused by ''S. epidermidis'' affect hospital patients because these organisms develop structures called biofilms on the surface of implanted medical devices. These biofilms result from the agglomeration of bacterial cells that are contained in an exopolysaccharide matrix, the slime, to produce a very dense and protected environment from the host defense systems and antibiotics. They not only provide protection from the host but they also result in the damage of surrounding tissues of the host. | ||
Skin and tissues infections, post-surgical wounds are the common points of entry for infection by ''S. epidermis''. This bacterium accounts for most catheter-related infections, joint replacement infections, the majority of prosthetic cardiac valve infections and infections following | Skin and tissues infections, post-surgical wounds are the common points of entry for infection by ''S. epidermis''. This bacterium accounts for most catheter-related infections, joint replacement infections, the majority of prosthetic cardiac valve infections and infections following post-neurosurgical procedures.In addition, studies have reported that S. epidermidis is highly predominant in the milk and feces of breast-fed infants compared to formula-fed ones. However, whether or not the presence of these bacteria can cause infections in these children have not been determined. Interestingly, methicillin-resistant ''S. epidermidis'' was identified in the cause of nosocomial meningitis when prosthetic devices are used in a trauma case in 2003. Even though, the antibiotic, vancomycin, was the treatment of choice, it was not successful in the recovery of the patient. Instead, better results were obtained with the use of linezolid. Due to their high resistance to antimicrobial agents, other techniques have been employed to prevent infections which imply mechanical cleaning, the stopping of biofilm growth by the removal of essential nutrients, the inhibition of microbial attachments to surfaces, and biomass detachment. | ||
==Application to Biotechnology== | ==Application to Biotechnology== | ||
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| Staphylococcus epidermidis |
Description and significance
Staphylococcus epidermidis is a gram positive coccus, a normal inhabitant of the human skin that grows in clusters. It is an aerobic organism but is yet capable of growing anaerobically when placed in a standardized, complex medium of glucose. Research studies reveal that S. epidermidis lives in close association with S. aureus, a very destructive pathogen.
Even though a coagulase-negative gram bacterium, S. epidermidis has been lately classified among the most important pathogens responsible for divers nosocomial infections. Most strains are highly resistant to multiple antibiotics, such as penicillin, tetracycline, methicillin and many more, which makes it very difficult to treat the infections resulting from these bacteria. According to the Centers for Disease Control and Prevention's National Nosocomial infection surveillance system, S. epidermidis is responsible for 33.5% of nosocomial blood stream infections.
Genome structure
Cell structure and metabolism
Ecology
Pathology
Most infections caused by S. epidermidis affect hospital patients because these organisms develop structures called biofilms on the surface of implanted medical devices. These biofilms result from the agglomeration of bacterial cells that are contained in an exopolysaccharide matrix, the slime, to produce a very dense and protected environment from the host defense systems and antibiotics. They not only provide protection from the host but they also result in the damage of surrounding tissues of the host.
Skin and tissues infections, post-surgical wounds are the common points of entry for infection by S. epidermis. This bacterium accounts for most catheter-related infections, joint replacement infections, the majority of prosthetic cardiac valve infections and infections following post-neurosurgical procedures.In addition, studies have reported that S. epidermidis is highly predominant in the milk and feces of breast-fed infants compared to formula-fed ones. However, whether or not the presence of these bacteria can cause infections in these children have not been determined. Interestingly, methicillin-resistant S. epidermidis was identified in the cause of nosocomial meningitis when prosthetic devices are used in a trauma case in 2003. Even though, the antibiotic, vancomycin, was the treatment of choice, it was not successful in the recovery of the patient. Instead, better results were obtained with the use of linezolid. Due to their high resistance to antimicrobial agents, other techniques have been employed to prevent infections which imply mechanical cleaning, the stopping of biofilm growth by the removal of essential nutrients, the inhibition of microbial attachments to surfaces, and biomass detachment.