Cephalosporin: Difference between revisions
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{{Image|Cephalosporin base.jpg|right|200px|Base structure of all cephalosporins.}} | |||
'''Cephalosporins''' are a class of [[antibiotic]] compounds sharing a common base structure, 7-aminocephalosporanic acid (7-ACA), that was derived from the first cephalosporin discovered, [[cephalosporin C]]. [[Penicillin]]s are very similar, although they contain a five-membered ring in place of the six-membered ring present in the cephalosporin. The activity of cephalosporins, penicillins, and some other antibiotics are due to the presence of a [[lactam|beta-lactam]], which binds irreversibly, via acylation, to penicillin-binding proteins, thereby inhibiting the peptidogycan layer of bacterial cell wall synthesis. Cephalosporins are often made semisynthetically. Cephalosporins and the very closely related[[cephamycin]]s are collectively referred to as [[cephems]]. | '''Cephalosporins''' are a class of [[antibiotic]] compounds sharing a common base structure, 7-aminocephalosporanic acid (7-ACA), that was derived from the first cephalosporin discovered, [[cephalosporin C]]. [[Penicillin]]s are very similar, although they contain a five-membered ring in place of the six-membered ring present in the cephalosporin. The activity of cephalosporins, penicillins, and some other antibiotics are due to the presence of a [[lactam|beta-lactam]], which binds irreversibly, via acylation, to penicillin-binding proteins, thereby inhibiting the peptidogycan layer of bacterial cell wall synthesis. Cephalosporins are often made semisynthetically. Cephalosporins and the very closely related[[cephamycin]]s are collectively referred to as [[cephems]]. | ||
Revision as of 05:31, 8 June 2009
Cephalosporins are a class of antibiotic compounds sharing a common base structure, 7-aminocephalosporanic acid (7-ACA), that was derived from the first cephalosporin discovered, cephalosporin C. Penicillins are very similar, although they contain a five-membered ring in place of the six-membered ring present in the cephalosporin. The activity of cephalosporins, penicillins, and some other antibiotics are due to the presence of a beta-lactam, which binds irreversibly, via acylation, to penicillin-binding proteins, thereby inhibiting the peptidogycan layer of bacterial cell wall synthesis. Cephalosporins are often made semisynthetically. Cephalosporins and the very closely relatedcephamycins are collectively referred to as cephems.
Nomenclature
Because the original cephalosporins used the "ceph" form of the spelling and were often trademarked, the International Nonproprietary Names (INN) suggested by the World Health Organization use the "cef" spelling for the generic drug name of all cephalosporins.
First generation cephalosporins
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazaflur
- Cefazedone
- Cefazolin
- Cefradine
- Cefroxadine
- Ceftezole
Second generation cephalosporins
In general, second generation cephalosporins have a broader spectrum of activity against Gram-negative bacteria.