Stavudine: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
(Chem infobox)
imported>David E. Volk
m (fix formula in chem box)
Line 6: Line 6:
|molname=stavudine
|molname=stavudine
|synonyms=  '''Zerit®'''
|synonyms=  '''Zerit®'''
|molformula= C<sub>35</sub>H<sub>38</sub>C<sub>l2</sub>N<sub>8</sub>O<sub>4</sub>
|molformula= C<sub>10</sub>H<sub>12</sub>N<sub>2</sub>O<sub>4</sub>
|molmass= 224.2133  
|molmass= 224.2133  
|uses=HIV/AIDS
|uses=HIV/AIDS

Revision as of 13:52, 24 March 2008

This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
Stavudine structure.jpg
stavudine
IUPAC name: see Chemistry
Synonyms: Zerit®
Formula: C10H12N2O4

 Uses: HIV/AIDS

 Properties: thymidine-like RT inhibitor

 Hazards: see Drug interactions

Mass (g/mol): CAS #:
224.2133 3056-17-5



Stavudine is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythymidine) , antiviral drug that inhibits reverse transcriptase and is used to treat against HIV/AIDS sold under the brand name Zerit®. It is in the drug class nucleoside reverse transcriptase inhibitor (NRTI). The phosphorylated form is the active compound that competes with deoxythymidine triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.


Chemistry

The IUPAC chemical name for stavudine is 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione, and it has a molecular formula C10H12N2O4, giving it a molecular mass of 224.2133 g/mol.

External links