Fluvastatin: Difference between revisions
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{{Image|Fluvastatin structure.jpg|right|200px|Fluvastatin, a type II statin.}} | |||
'''Fluvastatin''', also called luvastatina (Spanish) fluvastatine (French), fluvastatinum (Latin) and fluindostatin, is a type II statin used for the treatment of high cholesterol levels ([[hypercholesterolemia]]), the prevention of [[myocardial infarction|heart attacks]] and [[stroke]]s, and to diminish [[atherosclerosis|arterial plaque]] formation. It is used to reduce levels of total cholesterol, LDL-cholesterol, [[triglyceride]]s and apo B. It was the first synthetically derived [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] and like the other type II statins, [[carivastin]], [[atorvastatin]] and [[rosuvastatin]], it is based on an fluorophenyl structure rather than the naphtha ring system present in the type I statins [[mevastatin]], [[lovastatin]], [[pravastatin]] and [[simvastatin]]. Suppression of HMG-CoA reductase decreases production of [[mevalonate]], a key chemical precursor of [[cholesterol]]. | '''Fluvastatin''', also called luvastatina (Spanish) fluvastatine (French), fluvastatinum (Latin) and fluindostatin, is a type II statin used for the treatment of high cholesterol levels ([[hypercholesterolemia]]), the prevention of [[myocardial infarction|heart attacks]] and [[stroke]]s, and to diminish [[atherosclerosis|arterial plaque]] formation. It is used to reduce levels of total cholesterol, LDL-cholesterol, [[triglyceride]]s and apo B. It was the first synthetically derived [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] and like the other type II statins, [[carivastin]], [[atorvastatin]] and [[rosuvastatin]], it is based on an fluorophenyl structure rather than the naphtha ring system present in the type I statins [[mevastatin]], [[lovastatin]], [[pravastatin]] and [[simvastatin]]. Suppression of HMG-CoA reductase decreases production of [[mevalonate]], a key chemical precursor of [[cholesterol]]. | ||
Revision as of 07:03, 8 June 2009
Fluvastatin, also called luvastatina (Spanish) fluvastatine (French), fluvastatinum (Latin) and fluindostatin, is a type II statin used for the treatment of high cholesterol levels (hypercholesterolemia), the prevention of heart attacks and strokes, and to diminish arterial plaque formation. It is used to reduce levels of total cholesterol, LDL-cholesterol, triglycerides and apo B. It was the first synthetically derived HMG-CoA reductase inhibitor and like the other type II statins, carivastin, atorvastatin and rosuvastatin, it is based on an fluorophenyl structure rather than the naphtha ring system present in the type I statins mevastatin, lovastatin, pravastatin and simvastatin. Suppression of HMG-CoA reductase decreases production of mevalonate, a key chemical precursor of cholesterol.
Its official IUPAC chemical name is (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid and its chemical formula is C24H26FNO4.
brand names
Fluvastatin is sold in the following brand name products.
- Cranoc®
- Lescol®
- Lescol XL®
- Canef®
External links
The most up-to-date information about Fluvastatin and other drugs can be found at the following sites.
- Fluvastatin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Fluvastatin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Fluvastatin - Detailed information from DrugBank.