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| Dicer_Giardia.jpg
| | == Summary == |
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| One molecule of the Dicer-homolog protein from the protist Giardia intestinalis, colored by domain (PAZ domain yellow, platform domain red, connector helix blue, RNase and bridge domains green). Dicer is an RNase that cleaves long double-stranded RNA molecules into short interfering RNAs (siRNAs) as a first step in the RNA interference response, and also initiates the formation of the RNA-induced silencing complex (RISC).
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| Quoting caption in Wikipedia RNAi article:
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| "One molecule of the Dicer protein from Giardia intestinalis, which catalyzes the cleavage of dsRNA to siRNAs. The RNase domains are colored green, the PAZ domain yellow, the platform domain red, and the connector helix blue. The distance between the RNase and PAZ domains, determined by the length and angle of the connector helix, has been suggested as the determinant for the length of siRNA molecules produced by a given Dicer variant."
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| Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA. (2006). Structural basis for double-stranded RNA processing by Dicer. Science 311(5758):195-8. Entrez PubMed 16410517
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| Source
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| Self created from PDB entry 2FFL using the freely available visualization and analysis package VMD raytraced with POV-Ray 3.6
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| Date
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| 6 Oct 2006
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| Author
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| Opabinia regalis
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| Permission
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| GFDL
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| [edit] Licensing
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| I, the author of this work, hereby publish it under the following license:
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| GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".
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