BRCA1 gene: Difference between revisions
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Latest revision as of 12:00, 15 July 2024
In physiology, BRCA1 gene (BRCA-1 gene) is "a tumor suppressor gene located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."[1]
Women who have BRCA1 or BRCA2 gene mutations, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]
References
- ↑ Anonymous (2024), BRCA1 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637