Nitrofurantoin
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In medicine, nitrofurantion is an antibiotic that is a "urinary anti-infective agent effective against most Gram-positive and Gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression."[1]
Nitrofurantoin achieves good renal and urinary concentrations, but not serum good concentrations.[2]
Effectiveness
Randomized controlled trials have shown nirofurantion to be equivalent to trimethoprim-sulfamethoxazole[3] and ciprofloxacin[3][4] in treating uncomplicated urinary tract infections (cystitis).
References
- ↑ Anonymous (2023), Nitrofurantoin (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Pham P, Bartlett JG (2008). Nitrofurantion. Johns Hopkins Antibiotic Guide. Retrieved on 2008-10-05.
- ↑ 3.0 3.1 Iravani A, Klimberg I, Briefer C, Munera C, Kowalsky SF, Echols RM (March 1999). "A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection". The Journal of antimicrobial chemotherapy 43 Suppl A: 67–75. PMID 10225575. [e]
- ↑ Gupta K, Hooton TM, Roberts PL, Stamm WE (November 2007). "Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women". Archives of internal medicine 167 (20): 2207–12. DOI:10.1001/archinte.167.20.2207. PMID 17998493. Research Blogging.