Natriuretic peptide
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In physiology, natriuretic peptides are "Peptides that regulate the water-electrolyte balance in the body, also known as natriuretic peptide hormones. Several have been sequenced (atrial natriuretic factor; brain natriuretic peptide; c-type natriuretic peptide)."[1] In addition, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an inactive peptide that is co-secreted with brain natriuretic peptide.[2]
Brain natriuretic peptide and N-terminal pro-B-type natriuretic peptide are used as diagnostic tests to detect heart failure.[3][4] Both have a sensitivity over 90% but have a specificity of less than 70%.[3][4]
BNP levels do not elevate much in right heart failure unless the right heart pressure is elevated.[5]
References
- ↑ Anonymous (2023), Natriuretic peptide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Steinhart B, Thorpe KE, Bayoumi AM, Moe G, Januzzi JL, Mazer CD (2009). "Improving the diagnosis of acute heart failure using a validated prediction model.". J Am Coll Cardiol 54 (16): 1515-21. DOI:10.1016/j.jacc.2009.05.065. PMID 19815122. Research Blogging.
- ↑ 3.0 3.1 Mant J, Doust J, Roalfe A, Barton P, Cowie MR, Glasziou P et al. (2009). "Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care.". Health Technol Assess 13 (32): 1-207, iii. DOI:10.3310/hta13320. PMID 19586584. Research Blogging.
- ↑ 4.0 4.1 Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M et al. (2006). "Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure.". Evid Rep Technol Assess (Full Rep) (142): 1-147. PMID 17764210.
- ↑ Nagaya N, Nishikimi T, Okano Y, Uematsu M, Satoh T, Kyotani S et al. (1998). "Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension.". J Am Coll Cardiol 31 (1): 202-8. PMID 9426041. [e]